Colorectal Cancer Incidence in Steatotic Liver Disease (MASLD, MetALD, and ALD).

ABSTRACT:

Background & aims

Obesity and alcohol consumption are established risk factors for colorectal cancer (CRC). Recently, a multisociety consensus group has introduced a new classification for steatotic liver disease (SLD), which encompasses metabolic dysfunction-associated steatotic liver disease (MASLD), MASLD and increased alcohol intake (MetALD), and alcohol-associated liver disease (ALD). However, the risk of developing CRC in each of these SLD subgroups is unknown. This nationwide cohort study investigated the risk of CRC in MASLD, MetALD, and ALD patients. The primary endpoint was the occurrence of CRC in each SLD subgroup.

Methods

We conducted a nationwide, population-based study that included 1,497,813 patients diagnosed with MASLD, MetALD, or ALD, alongside 4,885,536 i

SUBMITTER: Kimura T 

PROVIDER: S-EPMC12441595 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature