Ischemic Injury Drives Nascent Tumor Growth Via Accelerated Hematopoietic Aging.

ABSTRACT:

Background

Patients with peripheral artery disease have an increased risk of cancer development. Aging-associated changes in hematopoietic stem and progenitor cells (HSPCs), including inflammation and increased myelopoiesis, are implicated in both cardiovascular disease and cancer, but their contributions to cardiovascular disease-driven tumor progression are unclear.

Objectives

This study sought to study tumor growth after peripheral ischemia and consequent changes within the HSPC bone marrow compartment to uncover mechanisms through which altered hematopoiesis promotes cancer.

Methods

Mammary cancer (E0771) growth was monitored in C57BL/6J mice after hind limb ischemia (HLI) or sham surgery. The tumor immune microenvironment, circulatory immune cells, and HSPC compa

SUBMITTER: Newman AAC 

PROVIDER: S-EPMC12441627 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature