T Cell Exhaustion and Function State Correlated With Outcomes in Patients With Intra-Abdominal Candidiasis.

ABSTRACT:

Introduction

Intra-abdominal candidiasis (IAC) still has a high mortality rate despite prompt antifungal therapy due to immunosuppression. T cell exhaustion is an important manifestation of immunosuppression. This study aimed to explore the expression pattern of exhaustion-related molecules in patients with IAC and determine the possible association between dynamic trends and prognosis.

Methods

Patients with IAC were enrolled, and non-IAC critically ill patients were included as controls. Peripheral blood mononuclear cells (PBMCs) were analysed by flow cytometry to determine the expression levels of T cell exhaustion-related markers. T cells isolated from PBMCs were stimulated by IL-2 in α-CD3/α-CD28 medium to compare intracellular cytokine production and proliferative capac

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12441659 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature