FAPI-engineered nanoprobe induces dual-cell ferroptosis therapy and enables light-up magnetic resonance imaging for gastric cancer peritoneal metastasis.

ABSTRACT: Gastric cancer with peritoneal metastasis (GC PM) is associated with poor prognosis and limited therapeutic options. Cancer-associated fibroblasts (CAFs), as critical components of the tumor microenvironment (TME), drive tumor progression and confer treatment resistance. Single-cell RNA-seq analysis of gastric cancer specimens revealed that GPX4 expression was elevated in CAFs, indicating their intrinsic resistance to ferroptosis. To overcome this stromal barrier, we developed a multifunctional theranostic nanoprobe, integrating ferroptosis induction, CAF-targeted delivery, and magnetic resonance imaging (MRI). The nanoprobe co-delivers cisplatin (CDDP) and mesoporous superparamagnetic iron oxide nanoparticles (MSPIONs) to enhance lipid peroxidation and is further modified with fibroblast

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12441704 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature