Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids.

ABSTRACT:

Introduction

Polygenic risk score (PRS) identifies individuals at high genetic risk for Alzheimer's disease (AD), but its utility in predicting cognitive trajectories and AD pathologies remains unclear. We optimized PRS (optPRS) for AD, investigated its association with cognitive trajectories and AD phenotypes of cerebral organoids.

Methods

Using genome-wide association study (GWAS) summary statistics from a European population, we developed optPRS to predict AD in Korean individuals (n = 1634). We analyzed the association between optPRS and cognitive trajectories (n = 771). We generated induced pluripotent stem cell-derived cerebral organoids from patients with high (n = 3) and low (n = 4) optPRS to evaluate amyloid beta (Aβ) and phosphorylated tau (p-tau) levels.

Result

SUBMITTER: Chun MY 

PROVIDER: S-EPMC12441735 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature