Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype.

ABSTRACT:

Introduction

Risk factors associated with sporadic non-amnestic and early-onset Alzheimer's disease (AD) remain underexamined.

Methods

We investigated a large, clinically heterogeneous, AD cohort for frequencies of established risk factors (hypertension, hypercholesterolemia, diabetes mellitus) alongside novel factors (non-right-handedness, learning disability, seizures, autoimmune disease).

Results

Early-onset AD possessed lower frequencies of established risk factors (hypertension, hypercholesterolemia, diabetes mellitus, all p < 0.001) and higher frequencies of novel factors (non-right-handedness, learning disability, active seizure, all p < 0.001; remote seizure, p = 0.002; and autoimmune disease, p = 0.007). An age at onset < 70 maximally distinguished novel from

SUBMITTER: Miller ZA 

PROVIDER: S-EPMC12441736 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature