The serine palmitoyl transferase of plant pathogenic fungi: a promising new target for the development of novel crop protection solutions^†.

ABSTRACT:

Background

Plant pathogens pose a significant threat to global agriculture and, thus to world food supplies, requiring the development of fungicides with new modes of action. Pyridazine carboxamides (PCs) represent a novel class of fungicides that inhibit serine palmitoyl transferase (SPT), an enzyme crucial for sphingolipid biosynthesis in fungi. The efficacy and the mechanism of action of PCs is explored in this study, highlighting their potential as a new fungicidal compound class effective on a wide range of Ascomycota pathogen.

Results

PCs demonstrate a strong biological efficacy against a broad range of Ascomycetes in in vitro and in planta assays, although they are less effective against the wheat pathogen Zymoseptoria tritici. PC resistant ultraviolet (UV)-mutants of

SUBMITTER: Nicolas L 

PROVIDER: S-EPMC12441766 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature