Beyond NACC's Uniform Data Set for cognition: the impact of additional items on measurement precision.

ABSTRACT:

Introduction

We sought to determine the implications of integrating additional cognitive test items beyond the items of the Uniform Data Set (UDS) administered by Alzheimer's Disease Research Centers (ADRCs).

Methods

We considered the UDS 1&2 and UDS 3 cognitive batteries alone ("UDS-only") and compared them to batteries augmented with additional items ("UDS-augmented") administered by the University of Pittsburgh, ADRC. We used confirmatory factor analyses to co-calibrate and harmonize three cognitive domains (memory, executive functioning, and language). Then we compared the UDS-only and UDS-augmented with respect to measurement precision, sample sizes required to detect 25% differences in rates of decline, and association between baseline scores and the hazard of converti

SUBMITTER: Choi SE 

PROVIDER: S-EPMC12441808 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature