Imaging Developmental Trajectories of Laminar Magnetic Susceptibility Throughout Adulthood in Human Brain Cortex.

ABSTRACT: Iron, myelin, and proteins are critical for neural integrity and cognitive function, yet their concentrations and distributions in brain tissue vary significantly across the lifespan. This natural variability necessitates age-specific reference ranges that account for developmental and aging-related changes. Noninvasive imaging techniques, such as Quantitative Susceptibility Mapping (QSM) and R2* imaging, provide complementary insights into these dynamics. Although age-related susceptibility trajectories have been well characterized in subcortical regions, systematic investigations of laminar susceptibility across the entire cortex remain limited. In this study, we analyzed QSM and R2* images from 447 healthy adults (18-80 years) to characterize cortical susceptibility profiles. Rather tha

SUBMITTER: Wang X 

PROVIDER: S-EPMC12441809 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature