The impact of mycobacteria-induced trained immunity on SARS-CoV-2 vaccine responses.

ABSTRACT:

Introduction

Beyond the role of Bacillus Calmette-Guérin (BCG) for tuberculosis prevention, BCG has demonstrated heterologous protective effects. The global health crisis caused by the SARS-CoV-2 virus led to research on whether BCG-induced trained immunity could strengthen antiviral defenses. However, studies reported quite different results on its effect against COVID-19.

Methods and results

In this study, we evaluated the impact of pre-existing trained immunity induced by a BCG-derived Mycobacterium bovis strain (dpB), in both live and inactivated forms, in combination with SARS-CoV-2 vaccination prior to challenge in a mouse model. While the SARS-CoV-2 vaccine was enough for protection in morbidity and mortality terms, its combination with live dpB significantly e

SUBMITTER: Sanchez-Morales L 

PROVIDER: S-EPMC12441830 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature