Identification of hub genes predicting sensitivity to neoadjuvant chemoradiation in locally advanced rectal cancer.

ABSTRACT:

Background

Preoperative neoadjuvant chemoradiation (NACR) benefits disease control in most locally advanced rectal cancer (LARC) patients. However, effective biomarkers predicting response to NACR are still not accessible. This study aimed to find potential biomarkers to assess therapy response and susceptibility to LARC.

Materials and methods

Differentially expressed genes (DEGs) between NACR-sensitive and resistant patients were screened using GEO database. STRING and Cytoscape were utilized to construct PPI networks and identify hub genes. Based on CIBERSORT, TCGA, GTEx, GSEA and ROC curves, the connections between hub genes and specific signaling pathways, immune cell infiltration, prognosis value and miRNA-transcription factor (TF)-target network were investigated. Huma

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC12441892 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature