Piezoelectric electrospun scaffold incorporating ibuprofen loaded ultrasound-responsive mesoporous silica nanoparticles for tissue regeneration.

ABSTRACT: Inflammation plays a pivotal role in tissue repair, and its modulation is crucial to avoid excessive immune activation or suppression. Three-dimensional scaffolds that can control the release of anti-inflammatory agents over time and space offer a promising approach to regulate the immune response while providing structural support during healing. In this study, we developed an electrospun biomimetic scaffold incorporating ibuprofen-loaded mesoporous silica nanoparticles with an ultrasound-responsive alginate coating. Optimal parameters for safe and non-invasive ultrasound stimulation (i.e., frequency, intensity, and duration) were identified to induce weakening of the interaction among the alginate chains, enabling on-demand drug release from the nanoparticles. In vitro stud

SUBMITTER: Benedetto Mas A 

PROVIDER: S-EPMC12442029 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature