Immunohistochemical characterization and potential prognostic relevance of dopamine signaling in canine pulmonary adenocarcinoma.

ABSTRACT:

Introduction

Dopamine signaling contributes to tumor progression in human lung adenocarcinoma. Isoforms of dopamine-and-cAMP-regulated phosphoprotein Mr. 32,000 (DARPP-32) are overexpressed in human lung adenocarcinoma and are associated with prognosis and development of treatment resistance. Despite similarities to human lung adenocarcinoma, dopamine signaling has not yet been evaluated in canine pulmonary adenocarcinoma. The objective of this study was to characterize immunohistochemical expression of DARPP-32 isoforms in canine pulmonary adenocarcinoma and assess associations with clinical variables, markers of proliferation and angiogenesis, and outcome.

Methods

Immunohistochemistry for DARPP-32 isoforms DARPP_N and DARPP_C, EGFR, D2R, and VEGFR2 was

SUBMITTER: Kuzmik AR 

PROVIDER: S-EPMC12442036 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature