SARS-CoV-2 incidence, seroprevalence, and antibody dynamics in a rural, population-based cohort: March 2020-July 2022.

ABSTRACT: Studies of SARS-CoV-2 incidence are important for response to continued transmission and future pandemics. We followed a rural community cohort with broad age representation with active surveillance for SARS-CoV-2 identification from November 2020 through July 2022. Participants provided serum specimens at regular intervals and after SARS-CoV-2 infection or vaccination. We estimated the incidence of SARS-CoV-2 infection identified by study reverse transcriptase-polymerase chain reaction, electronic health record documentation or self-report of a positive test, or serology. We also estimated the seroprevalence of SARS-CoV-2 spike and nucleocapsid antibodies measured by ELISA. Overall, 65% of the cohort had ≥ 1 SARS-CoV-2 infection by July 2022, and 19% of those with primary infection were r

SUBMITTER: Petrie JG 

PROVIDER: S-EPMC12442051 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature