Long-Term Neuroimaging Findings in a Murine Model of Human Extraparenchymal Neurocysticercosis.

ABSTRACT: Neurocysticercosis is caused by the establishment of Taenia solium cysticerci in the central nervous system. The extraparenchymal form (ExP-NCC) is the most severe clinical presentation that may remain asymptomatic for years. Current treatment involves cysticidal drugs (albendazole and/or praziquantel) combined with glucocorticoids to manage the associated neuroinflammation; however, only ∼30% of patients respond effectively. This highlights the need to improve therapeutic strategies. Herein, the experimental murine model of human ExP-NCC was further characterized to improve its usefulness in testing new therapies. In humans, cysts grow slowly in the basal cisterns of the subarachnoid space, and patients become symptomatic years after the infection. Thus, a long-term follow-up was p

SUBMITTER: Mendez A 

PROVIDER: S-EPMC12442056 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature