Surface-Engineered HA-PEG-ICG/PLGA Nanoprobes with Vessels Targeting for Lymphatic System Visualization.

ABSTRACT: Targeted imaging of the lymphatic system is essential for the early diagnosis and management of lymphatic disorders, such as lymphedema. In this study, we developed a lymphatic-targeted fluorescent nanoprobe by encapsulating indocyanine green (ICG) within poly(lactic-co-glycolic acid) (PLGA) nanoparticles, further surface-modified with hyaluronic acid-polyethylene glycol (HA-PEG) to enhance specificity (HA-PEG-ICG/PLGA NPs). The nanoparticles were synthesized via a microemulsion technique followed by surface cross-linking, and thoroughly characterized by ultraviolet-visible (UV-vis) spectroscopy, fluorescence emission analysis, Fourier transform infrared (FTIR) spectroscopy, and ζ-potential measurements, confirming their physicochemical stability and functionalization. In

SUBMITTER: Chiang HH 

PROVIDER: S-EPMC12442094 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature