Water-Driven Oxygen and Nitric Oxide Release from Porphyrin- and Mn-Based Metal-Organic Framework Enables Accelerated Acute Wound Healing.

ABSTRACT: Medical gases, particularly oxygen and nitric oxide (NO), have attracted significant interest in clinical applications, notably wound healing, due to their role in enhancing cell proliferation, angiogenesis, and collagen deposition. However, the use of these gases has been limited by challenges such as inefficient gas delivery and potential toxicity to normal tissues. In this study, we elucidate a feasible approach using a porphyrin-based metal-organic framework (MOF), a unique material that shows immense potential for dual-gas-assisted wound healing. The MOF nanorods, meticulously designed, contain catalytically active manganese clusters, enabling spontaneous water decomposition and subsequent oxygen generation upon water exposure. The MOF incorporates Fe-chelated porphyrins, which not on

SUBMITTER: Wang JN 

PROVIDER: S-EPMC12442097 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature