Theranostic Gold Nanoparticles Encapsulated in a PEGylated Liposome as an Effective Radiosensitizer for Cancer Radiation Therapy.

ABSTRACT: High-Z materials enhance radiation dose deposition primarily through strong photoelectric absorption. Leveraging this property, nanoparticles based on high-Z content materials can be utilized as nanoscale radiosensitizers to enhance the efficacy of radiotherapy. Notably, gold nanoparticles (Au: gold, AuNPs) have been intensively investigated due to their excellent radiosensitizing effect and straightforward synthesis process. However, without additional modifications, they suffer from unfavorable biodistribution and inefficient tumor targeting, which limit their efficacy as radiosensitizers. Herein, we developed ultrasmall AuNPs encapsulated in PEGylated liposome (PEG: polyethylene glycol, Au-Lipo) and optimized their PEGylated lipid composition to improve their performance as radiosensiti

SUBMITTER: Choi J 

PROVIDER: S-EPMC12442100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature