A Data-Driven Hydrophobicity Scale for Predicting Liquid-Liquid Phase Separation of Proteins.

ABSTRACT: An accurate model for macroscale disordered assemblies of biological macromolecules such as those formed in so-called membraneless organelles would greatly assist in studying their structure, function, and dynamics. Recent evidence has suggested that liquid-liquid phase separation (LLPS) underlies the formation of membraneless organelles. While the general mechanism of exchange of macromolecule/water for macromolecule/macromolecule interactions is known to be the driving force for LLPS, the specific interactions involved are not well understood. One way that protein-water and protein-protein interactions have been understood historically is via hydrophobicity scales. However, these scales are typically optimized for describing these relative interactions in certain cases, such as protein f

SUBMITTER: Dannenhoffer-Lafage T 

PROVIDER: S-EPMC12442143 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature