A Thermostable Fatty Acid Hydratase from Marinitoga Piezophila with Low Temperature Optimum and Broad Product Scope.

ABSTRACT: Hydroxy fatty acids (HFAs) are valuable derivatives of fatty acids (FAs) with interesting bioactivities. Moreover, they are used in materials industry as additives, starting materials and surfactants. HFAs can be produced from FAs either by hydroxylation or by hydration reaction, if FA is unsaturated, using chemical or enzymatic methods. FA hydratases (FAHs) are promising biocatalysts for HFA synthesis thanks to their non-redox nature, high efficiency and excellent selectivity. Although FAHs are relatively more stable compared to other enzymes like monooxygenases, their tolerance to high temperature and organic solvents is limited. In this study, we characterized a rare thermostable FAH ortholog through database gene mining. This enzyme from Marinitoga Piezophila, a thermo-piezophilic orga

SUBMITTER: Johnsen NK 

PROVIDER: S-EPMC12442217 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature