Palladium-Catalyzed Allylic C-F Bond Functionalization of Pentafluoroethyl Alkenes with Heteroatom Nucleophiles.

ABSTRACT: A diastereoselective Pd-catalyzed allylic C-F bond functionalization of pentafluoroethyl alkenes is described. Heteroatom nucleophiles including amines, alcohols, and thiols can be employed to construct new C-N, C-O, or C-S bonds with concomitant cleavage of an allylic C-F bond. Both 1,1- and 1,2-disubstituted pentafluoroalkenes can be utilized to synthesize novel tetra- and trisubstituted alkenes containing an sp²-carbon connected to both F and CF₃ in good to excellent diastereoselectivities.

SUBMITTER: Fu Z 

PROVIDER: S-EPMC12442228 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature