Rotavirus Vaccine Effectiveness Stratified By National-Level Characteristics: An Introduction to the 24-Country MNSSTER-V Project, 2007-2023.

ABSTRACT:

Background

Rotavirus vaccines are moderately protective against illness in settings with high compared with low mortality rates. Vaccine effectiveness (VE) evaluations may clarify our understanding of these disparities, but estimates among key subpopulations and against rare outcomes are not available in many analyses due to sample size. We combined 25 data sets from test-negative design case-control evaluations in 24 countries that enrolled children with medically attended diarrhea, laboratory-confirmed rotavirus stool testing, and documented vaccination status. We calculated rotavirus VE stratified by country-level characteristics.

Methods

Children 3-59 months old with birthdates and surveillance hospital arrival dates were included; other variables were standardized as av

SUBMITTER: Burnett E 

PROVIDER: S-EPMC12442247 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature