A Framework for Anemia Differential Diagnosis in Paleopathology Incorporating Metric Methods.

ABSTRACT:

Objectives

This paper explores metric manifestations of anemia in crania undergoing growth and development using micro-CT imaging. It proposes a framework for assigning a most-likely diagnostic option for anemia, based on evaluating the parameters proposed in this study.

Materials and methods

Sixty-eight orbits/frontal bones of individuals aged birth to 15 years from Quebecois and Dutch archaeological collections dating to the 18th and 19th centuries underwent micro-CT analysis. Individuals were visually assessed for skeletal manifestations of marrow hyperplasia within the internal marrow space using a scoring rubric. Bone microarchitecture measurements were used to calculate T-scores and identify individuals who displayed potential manifestations of marrow hyperplasia. Rela

SUBMITTER: Morgan B 

PROVIDER: S-EPMC12442334 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature