The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol.

ABSTRACT: Traumatic stress is linked to problematic alcohol use, yet its persistent effects on alcohol sensitivity remain unclear. This study examined the long-term effects of traumatic stress on alcohol sensitivity in male and female Long-Evans rats. Rats were trained to discriminate alcohol (2 g/kg, i.g.) from water, and two weeks after a single, inescapable exposure to the predator odor stressor TMT, substitution for an alcohol dose curve and GABA_A agonism were assessed both systemically (pentobarbital, i.p.) and site-specifically [muscimol in the prelimbic cortex (PrL) or anterior insular cortex (aIC)]. Additional experiments in alcohol-naive rats examined the effects of TMT on alcohol-induced behaviors, c-Fos expression, and GABA_A receptor gene expression in the PrL and aI

SUBMITTER: Tyler RE 

PROVIDER: S-EPMC12442340 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature