Pathway crosstalk enables degradation of aromatic compounds in marine <i>Roseobacter</i> clade bacteria.

ABSTRACT: Aromatic compounds are essential raw materials for almost all sectors of human societies but also persistent environmental pollutants recalcitrant to biodegradation. The ocean serves as a significant sink for these compounds, while their biological conversion routes remain poorly understood, hindering a comprehensive understanding of the marine carbon cycle and advancements in bioremediation and biological carbon upcycling. Here, we report the degradation pathway of aromatic molecules in the marine Roseobacter clade bacteria through multi-omics analysis and CRISPR-Cas-based genome editing. Using Roseovarius nubinhibens and 4-hydroxybenzoate (4HB) as representatives, we identified the transport of 4HB via TRAP, ABC, and MFS transporters. Then, we deciphered the integral β-keto

SUBMITTER: Xu H-W 

PROVIDER: S-EPMC12442348 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature