Functional interplay between RND efflux pumps and GacS in <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic human pathogen that is ubiquitous in the environment. The environmental versatility of P. aeruginosa is often attributed to a large arsenal of active efflux pumps, low permeability of the outer membrane, and extensive regulatory networks. In this study, we analyzed putative functional interplay between polyspecific drug efflux pumps of the Resistance-Nodulation-Division (RND) superfamily of proteins and the GacSA two-component regulatory system. RND transporters are the major contributors to antibiotic resistance and survival under various environmental stresses, whereas GacSA is a global regulator and governs critical lifestyles during human colonization. We found that the inactivation of either RND pumps or gacS induces broa

SUBMITTER: Adamiak JW 

PROVIDER: S-EPMC12442375 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature