Impact of a defined bacterial community including and excluding <i>Megamonas hypermegale</i> on broiler cecal microbiota and resistance to <i>Salmonella</i> infection.

ABSTRACT: Intensive broiler production practices impair the transmission of commensal microbes from hens to offspring, resulting in a lower abundance of non-spore-forming strict anaerobic bacteria. We evaluated the effects of introducing a defined community (DC) of bacteria including and excluding Megamonas hypermegale to chicks prior to a Salmonella challenge. Inoculation with DC resulted in higher phylogenetic diversity (PD) and the dominance of Bacteroidetes species in the cecal microbiota, with a decrease in the relative abundance of Salmonella and Escherichia/Shigella, as well as a lower Enterobacteriaceae load. Substantial shifts in microbiota composition were coupled with subtle changes in metabolites and host responses, including changes in interferon-γ, ma

SUBMITTER: Schultz Marcolla C 

PROVIDER: S-EPMC12442376 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature