Time-resolved monitoring of yeast responses to lipopolysaccharide exposure by cell-released volatile organic compounds.

ABSTRACT: Volatile organic compound (VOC) profiles function as dynamic fingerprints of physiological states and disease progression. Here, the eukaryotic organism Saccharomyces cerevisiae was used to investigate the emission characteristics of VOCs induced by lipopolysaccharide (LPS). Using multi-omics techniques and physiology methods, yeast cells were observed to undergo both stress and adaptation phases upon exposure, as characterized by changes in acetic acid-D and higher alcohols/aldehydes. The oxidative phosphorylation process in yeast was inhibited during the stress response, leading to an oxidative stress accompanied by growth inhibition and cell wall remodeling. The adaptive stage of cells reprogrammed metabolism to consume excess metabolic substrates generated during the stress stag

SUBMITTER: Liu H 

PROVIDER: S-EPMC12442379 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature