Serotonergic and immunomodulatory properties of the psychobiotic candidate <i>Bacteroides finegoldii</i> UO.H1052 and its extracellular vesicles.

ABSTRACT: Bacteroides finegoldii UO.H1052, a human gut commensal, was evaluated for its potential psychobiotic and immunomodulatory properties. Whole-genome analysis confirmed the absence of virulence factors, plasmids, and antibiotic-resistance genes. Metabolomic profiling of cell-free supernatants (CFSs) and extracellular vesicle (EV) postbiotics revealed a high- and medium-dependent production of neuroactive metabolites, including γ-aminobutyric acid, tryptophan, tyrosine, and tyramine, as well as physiologically relevant levels of short-chain fatty acids, such as acetate, propionate, and butyrate. Functionally, CFS enhanced epithelial barrier integrity by increasing transepithelial electrical resistance and mitigating LPS-induced disruption in Caco2/HT29 monolayers without cytotoxic effec

SUBMITTER: Yousuf B 

PROVIDER: S-EPMC12442397 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature