Genomic evolution of <i>Salmonella</i> Dublin in cattle and humans in the United States.

ABSTRACT: Increasingly, antimicrobial-resistant (AMR) Salmonella Dublin is a threat to human and animal health, therefore requiring a One Health approach to comprehensively understand pathogen evolution. Moreover, S. Dublin dissemination throughout the United States and the food supply chain is a concern for food safety and security. Here, we leveraged multi-agency biosurveillance data and genomic sequencing of S. Dublin strains to provide a robust analysis of its evolution across human, animal, and environmental reservoirs. This study advances our understanding of AMR S. Dublin, elucidates factors driving AMR emergence, and informs interventions to protect public health. In total, 2,150 strains collected between 2002 and 2023 throughout the United States from clinical bo

SUBMITTER: Kenney SM 

PROVIDER: S-EPMC12442401 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature