Regulation of iron homeostasis by Fur and atypical response regulator SsoR via derepressor-inhibitor oscillation in <i>Shewanella oneidensis</i>.

ABSTRACT: Iron is a vital cofactor for enzymes essential to many biological processes, yet in excess, it poses a danger to all living organisms. In order to ensure survival and proliferation under fluctuating environmental iron levels, bacteria evolve sophisticated regulatory systems to maintain iron homeostasis. Unlike master regulator Fur, a large portion of other players remains poorly defined. Here, we characterized the physiological impacts of atypical phosphorylation-independent response regulator SsoR of Shewanella oneidensis, a γ-proteobacterium renowned for metabolic versatility. By combining transcriptomics, proteomics, and transposon screening, we discovered that the SsoR loss impairs growth and decreases cytochrome c content under iron-limited conditions. Further investigat

SUBMITTER: Jie K 

PROVIDER: S-EPMC12442407 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature