Functional constipation in Chinese infants: disruptions in gut microbiota and urinary metabolome revealed by a cross-sectional analysis.

ABSTRACT:

Background

Functional constipation (FC) is regarded as the most prevalent functional gastrointestinal disorder among children and is closely related to the intestinal microbiota. Nevertheless, there is a paucity of data regarding this relationship in Chinese infants.

Methods

In this study, we investigated the alterations in gut microbiota of 79 FC infants under 2 years of age in China, using 31 balanced non-constipated (BC) children as controls. Some clinical parameters were evaluated, fecal microbiota was analyzed using 16S rRNA gene sequencing, and urinary metabolites were profiled via UPLC-Q-TOF/MS method.

Results

Children with FC demonstrated significantly lower stool scale scores compared to BC group. Significant differences were observed in both microbial commun

SUBMITTER: Zhao H 

PROVIDER: S-EPMC12442431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature