Microbiota diversity and differences in the respiratory tract of children with pneumonia.

ABSTRACT:

Importance

Although studies have examined the link between microbiota and airways, the understanding of microbial imbalances in the upper respiratory tract (URT) and lower respiratory tract (LRT) in pediatric pneumonia remains limited.

Objective

To elucidate the microbial communities within these areas, shedding light on the microbiota's contribution to pneumonia progression and the underlying metabolic shifts.

Methods

Pharyngeal swabs and bronchoalveolar lavage fluid samples were gathered from children with pneumonia and sequenced for 16S rDNA gene. Microbiota composition and differences between URT and LRT were analyzed.

Results

Proteobacteria (40.91%), Firmicutes (25.61%), and Actinobacteria (12.77%) were the three most abundant phyla in

SUBMITTER: Ge D 

PROVIDER: S-EPMC12442450 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature