The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetes.

ABSTRACT: BackgroundType 2 diabetes (T2DM) is associated with brain abnormalities and cognitive dysfunction, including increased risk for Alzheimer's disease. However, the mechanisms of T2DM-related dementia remain poorly understood.ObjectiveWe evaluated the molecular properties of gray matter atrophy and cognitive decline in T2DM.MethodsWe obtained retrospective data from the Mayo Clinic Study of Aging for 271 individuals with T2DM and 542 non-diabetic controls (age 51-89, 62% male). We identified regions of significant gray matter atrophy in the T2DM group and then determined which genes were significantly expressed in these brain regions using imaging transcriptomics. We selected 15 candidate genes involved in insulin signaling, lipid metabolism, amyloid processing, N-methyl-D-aspartate-mediated

SUBMITTER: Kesler SR 

PROVIDER: S-EPMC12442454 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature