Geographic patterns of antibiotic resistance in the human gut microbiome: insights from metagenome-assembled genomes across four Chinese provinces.

ABSTRACT: Next-generation metagenomic sequencing has substantially advanced our understanding of the human intestinal microbiome. Many commensal microbes in the human gut carry a wide array of antibiotic resistance genes (ARGs), collectively forming the gut-associated resistome. In this study, we investigated the gut resistome using metagenomic sequencing. We collected 119 fecal samples from individuals in four Chinese provinces: Yunnan, Guizhou, Sichuan, and Jiangsu. By constructing metagenome-assembled genomes (MAGs) and comprehensive gene catalogs, we aimed to characterize the microbial community structure and assess the distribution of ARGs and mobile genetic elements (MGEs). Our results revealed significant regional differences in gut microbial composition. While Bacillota_A and Actinomycetota

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12442556 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature