Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization.

ABSTRACT: Angiogenesis is vital for tumor growth and metastasis, with tumor-associated macrophages (TAMs) being key pro-angiogenic cells recruited by tumor-secreted chemokines. High levels of TAMs contribute to tumor progression and antiangiogenic therapy resistance. Therefore, intensive study of the regulatory mechanisms of TAMs recruitment during tumor development is important for the discovery of new antitumor and antiangiogenic therapeutic strategies. Here, we found that in lung adenocarcinoma (LUAD), ENH levels positively correlated with microvessel density and TAMs infiltration. Further exploration revealed that ENH promoted LUAD angiogenesis and growth by stimulating TAMs recruitment and M2 polarization. Mechanistically, ENH in LUAD induced YAP nuclear aggregation to promote CCL5 transcriptio

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12442595 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature