Coordination Geometry Tuning in a Single-Atom Nanozyme to Mimic Metalloenzymes with Nonplanar Active Site.

ABSTRACT: Single-atom nanozymes (SAzymes) have been developed to mimic metalloenzymes by modulating their coordination environment. However, the impact of the coordination geometry at the metal center on the catalytic activity of the SAzymes, particularly those with nonplanar active site configurations, has been minimally explored. Here, the effects of the geometric configuration of the Zn-N₄ active sites on the catalytic activity of the carbonic anhydrase (CA)-mimetic SAzymes are reported. CA-mimetic SAzymes with Zn-N₄ active sites in tetrahedral, distorted tetrahedral, and square-planar configurations are prepared by simple temperature-controlled carbonization of ZIF-8. The SAzyme with the distorted tetrahedral Zn-N₄ configuration displays superior catalytic CO

SUBMITTER: Lee H 

PROVIDER: S-EPMC12442611 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature