Antibacterial and Proangiogenic Hydrogel Microneedle Patches for Wound Healing.

ABSTRACT: Wounds represent a global and challenging healthcare issue, resulting in a cascade of consequences. Despite the widespread application of existing wound dressings, their performance and efficacy are significantly limited in terms of biocompatible matrices and functionalization for promoting vascularization and antimicrobial activity. In this study, we propose a drug-loaded microneedle based on a copolymer hydrogel composed of methacrylated chitosan and polyethylene glycol diacrylate incorporating antimicrobial peptide and vascular endothelial growth factor. These microneedles were applied to wounds where their degradation facilitated the release of the loaded drugs to exert antibacterial and angiogenic effects. In vitro experiments demonstrated that our microneedles exhibit uniform morphol

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12442652 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature