Topographical Patterning of Cell-Repellent Interfaces for Immune-Stealth Implantable Electronics via Multiphoton Ablation Lithography.

ABSTRACT: Stable and reliable operation of implantable electronics must ensure both high-quality electrical performance and chronic biocompatibility. Here, immune-stealth implantable electronics fabricated by multiphoton ablation lithography are introduced. The cell-repellent interface, consisting of micro-grooves and nano-islands, can be created by laser-assisted topography patterning on a thin film substrate. This patterned surface demonstrates a 20-fold increase in cell-repellent effectiveness against immune cells such as macrophages and fibroblasts due to disturbance of focal adhesion. Furthermore, the cell-repellent interface can also be patterned on the sub-micron electrode layer without compromising its electrical and electrochemical performance. When the electrocardiogram (ECG) sensor applyi

SUBMITTER: Seo H 

PROVIDER: S-EPMC12442681 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature