Lysosome-Featured Cell Aggregate-Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post-Irradiation Endothelial Ferroptosis for Mandibular Regeneration.

ABSTRACT: Ferroptosis, a form of regulated cell death driven by iron accumulation and lipid peroxidation, is implicated in various diseases, but effective therapeutic strategies remain limited. Lysosomal impairments cause iron dysregulation and initiate ferroptosis, which potentially contribute to ionizing radiation-induced tissue damages. Here, the role of intercellular lysosomal regulation in governing iron homeostasis and protecting against ferroptosis is investigated in models of stem cell aggregation and mandibular regeneration post-irradiation. Lysosomes are discovered to accumulate in specific regions within multi-stem cell aggregates and regulate cell aggregate formation based on iron control, which is occurred through hypoxic signaling-driven lysosomal redistribution mediated by extracellul

SUBMITTER: Li YY 

PROVIDER: S-EPMC12442703 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature