Synergistic effects of triglyceride-glucose index and body mass index combined with depression in predicting stroke events: a study based on two national cohorts.

ABSTRACT:

Background

Stroke risk associated with the triglyceride-glucose index-body mass index (TyG-BMI) has been increasingly recognized. Depression has also been firmly established as a factor related to the development of stroke. However, there remains a research gap in evaluating the combined effect of TyG-BMI and depression on the risk of stroke. This study aims to address the inconsistency between TyG-BMI, depression, and stroke incidence.

Methods

This study utilized longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS), involving 6,417 participants, and the National Health and Nutrition Examination Survey (NHANES) database, which included data from 17,754 participants. The analytical approach involved applying Multivariate logistic regression analy

SUBMITTER: Jian H 

PROVIDER: S-EPMC12442736 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature