Flash Communication: Ti-Catalyzed "Interrupted" Cascading Hydroamination of 1,6- and 1,7-En-ynes.

ABSTRACT: Herein, we report a new hydroaminative cyclization for 1,6 and 1,7 en-ynes using a simple Ti imido precatalyst, [py₂TiCl₂(NPh)]₂. The well-known Ti imido + alkyne [2+2] azatitanacyclobutadiene cycloadduct intermediate can be further intercepted via insertion by tethered alkenes, followed by protonolysis of the resultant metallacycle to yield α-carbocyclic imine products through cascading C-N and C-C bond formation.

SUBMITTER: Rynders KJ 

PROVIDER: S-EPMC12442808 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature