Changes in monocyte subsets are associated with an increased risk of AAA and are surrogate markers for AAA morphology in patients with late-stage disease.

ABSTRACT:

Introduction

Monocytes play a role in the pathology of abdominal aortic aneurysm (AAA) and can display immunophenotypic heterogeneity. Alterations in monocyte subsets are associated with cardiovascular risk, but their profile in AAA is poorly understood.

Aim

We aimed to comprehensively define associations of monocyte phenotypes with AAA risk and AAA morphology.

Methods

Monocyte subsets (CD14++CD16-, CD14++/CD16+, and CD14+/CD16++) were analyzed in an observational study in patients with AAA (n = 33) and varicose veins (n = 33) using flow cytometry.

Results

Classical monocytes were 3% lower (p = 0.001) in AAA, while intermediate and non-classical monocytes were 1.8-fold (p = 0.019) and 1.9-fold (p = 0.025) higher in AAA, respectively. The di

SUBMITTER: Hamann B 

PROVIDER: S-EPMC12442832 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature