Mature interneuron subtypes arise from distinct spatial and temporal subdomains within the caudal ganglionic eminence.

ABSTRACT: Forebrain inhibitory interneurons are born from transient structures during embryogenesis known as the medial and caudal ganglionic eminences (MGE and CGE, respectively). The MGE and CGE generate distinct, non-overlapping cohorts of interneurons that can be defined by their transcriptomic, morphological, and electrophysiological characteristics. In the MGE, somatostatin-expressing (SST+) cells arise predominantly from the dorsal-posterior MGE from E12-E16 whereas parvalbumin-expressing (PV+) cells are born in the ventral-anterior MGE throughout embryogenesis. This relationship between spatiotemporal origin and mature interneuron subtypes has led to genetic insights regarding fate and maturation of these MGE-derived cells. A similar organization has never been explored in the CGE, despite t

SUBMITTER: Garg V 

PROVIDER: S-EPMC12443043 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature