Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.

ABSTRACT: Sub-millimeter resolution functional magnetic resonance imaging (fMRI) at ultra-high field (≥ 7T) has offered an unprecedented opportunity to probe mesoscopic computations at a columnar or laminar level. However, its application has been primarily restricted to the neocortex. Inferior brain regions, particularly the hippocampus (HC), are challenging targets for laminar fMRI. Recent developments in acquisition methods have shown the feasibility of laminar recordings in the HC using gradient-echo blood oxygenation level-dependent (BOLD) contrast. Nonetheless, the spatial specificity of the BOLD signal is compromised by the draining veins' bias. Cerebral blood volume (CBV)-sensitive sequences including vascular space occupancy (VASO) have emerged as a promising augmentation tool to capture th

SUBMITTER: Ahmadi K 

PROVIDER: S-EPMC12443046 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature