Diffusion tensor imaging in Chediak Higashi Disease.

ABSTRACT:

Aim

To define the natural history of diffusion tensor imaging (DTI) in Chediak-Higashi Disease (CHD) participants in relation to normative development.

Methods

Twenty-five DTI scans from 15 CHD participants were compared with 100 DTI scans from 100 neurotypical controls (NC). Comparisons were evaluated for DTI metrics including fractional anisotropy (FA), and mean, axial, and radial diffusivity (MD, AD, RD, respectively). Correlational tractography was also performed to identify group differences between CHD and NC.

Results

Pediatric CHD participants had DTI metrics similar to NC, however, progressive pathogenic increases in MD, AD, and RD were observed in CHD participants compared to NC in white matter pathways of the whole brain, corpus callosum, and cerebellum. Cor

SUBMITTER: Lewis CJ 

PROVIDER: S-EPMC12443054 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature