The absolute and relative concentration-response patterns of exposure to ambient air pollutants and the risk of Alzheimer's disease.

ABSTRACT: BackgroundExisting literature lacks information on the relationship between exposure to ambient air contaminants and Alzheimer's disease (AD) risk represented by simultaneous assessment of absolute and relative concentration-response patterns.ObjectiveThis study quantifies fine particulate matter (PM_2.5)-exposure and AD-risk relationships with detailed analyses of the role of methodologic limitations and sources of bias (e.g., population heterogeneity) and identifies notable subpopulation differences and subpopulations most vulnerable to PM_2.5 exposure.MethodsUsing Medicare and SEDAC data, we evaluated effects of PM_2.5 exposure on AD risk using absolute and relative concentration-response functions through, respectively, age-adjusted rates and Cox-model est

SUBMITTER: Akushevich I 

PROVIDER: S-EPMC12443162 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature