TSPO PET/MR in neuropsychiatric lupus: neuroinflammatory metabolic signatures and diagnostic biomarkers.

ABSTRACT:

Background

Neuropsychiatric SLE (NPSLE) is a clinically challenging subset of SLE, marked by heterogeneous central nervous system involvement. Diagnosis relies on clinical symptoms and exclusionary criteria, lacking objective biomarker.

Purpose

To investigate metabolic patterns of intracerebral lesions and identify diagnostic biomarkers for NPSLE using translocator protein (TSPO) positron emission tomography (PET)/magnetic resonance (MR).

Methods

A retrospective analysis was conducted on 19 patients with NPSLE and 10 patients with non-NPSLE, who underwent [¹⁸F] DPA-714 PET/MRI. Diagnoses of SLE and NPSLE followed American College of Rheumatology (ACR) classification and Systemic Lupus International Collaborating Clinics (SLICC) Model B criteria. T2-weighted

SUBMITTER: Huang J 

PROVIDER: S-EPMC12443175 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature