Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjogren's syndrome.

ABSTRACT:

Objectives

The central nervous system is a significant extraglandular target in primary Sjögren's syndrome (pSS), often characterised by cognitive deficits. However, the underlying mechanisms remain elusive. This study aims to investigate the alterations in amplitude of low-frequency fluctuations (ALFF) in patients with pSS and to explore whether it exhibits frequency dependence and temporal variability, attempting to explore its mechanism.

Methods

The study comprised 68 patients with pSS and 69 healthy controls, all of whom underwent resting-state functional MRI and neuropsychological assessments. The ALFF method was used to ascertain whether frequency-dependent alterations occur within the slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) frequency bands. Additionally, dy

SUBMITTER: Hu C 

PROVIDER: S-EPMC12443196 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature