VDR gene variants FokI and ApaI: Factors associated with susceptibility to multiple sclerosis.

ABSTRACT: Multiple Sclerosis (MS) is a commonly observed autoimmune inflammatory condition that affects the central nervous system (CNS). Vitamin D functions as a steroid hormone by interacting with its nuclear receptor, the vitamin D receptor (VDR), to regulate critical biological processes. The polymorphisms of the VDR gene have not yet been investigated in the cohort of MS patients in Jordan. We aimed to examine the genetic associations between polymorphisms in the VDR gene (specifically, TaqI, BsmI, ApaI, and FokI) and susceptibility to Multiple Sclerosis (MS). Additionally, we aimed to investigate the relationship between vitamin D status and VDR gene polymorphisms in relation to the onset of MS in Jordanian individuals. The study cohort included 218 individuals diagnosed with Multiple Sclerosi

SUBMITTER: Al-Eitan L 

PROVIDER: S-EPMC12443253 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature